A trustworthy, enthusiastic, and exceptionally skilled patent agent, Dr. Ming Zhang provides innovators with a potent combination of subject matter expertise and tailored, clear communication in her efforts to refine, protect, and commercialize their advancements. As fluent in the language of patent law as she is in both English and Mandarin, Ming is deeply committed to her clients’ success and has played an instrumental role in developing a wide range of impactful and cutting-edge technologies and solutions in the biotech industry.
With particularly extensive molecular biology knowledge and experience, Ming has collaborated closely with clients on genetic research and next-generation sequencing (NGS) technologies. She also possesses a robust technical background in immunology, functional genomics, genetics, gene therapy, gene expression vector design and delivery, molecular biology, and cell biology.
Ming’s work spans all aspects of the patent lifecycle. She drafts meticulous and unassailable patent applications focused not only on satisfying all legal requirements but also on aligning with the client’s specific objectives and intentions. Leveraging her well-honed communication and organizational talents, she crafts effective responses to Office Actions across different jurisdictions and manages foreign filings across the globe. Her attention to detail serves her clients well when she performs due diligence, including patentability searches and freedom-to-operate analyses.
Personable, responsive, and passionate about her work in equal measure, Ming has cultivated and developed strong business partnerships with top IP law firms, significantly increasing the number of inbound patent applications and trademark cases filed in China. With her tireless work ethic, intellectual curiosity, and technical and legal know-how, Ming is an invaluable asset to today’s innovators and inventors.
Education
- Post-Master’s Certificate, Sequence Analysis and Genomics, Johns Hopkins University, 2014
- Doctor of Science, Molecular Biology and Biochemistry, Nankai University, College of Life Science, 2008
- Bachelor of Science, Biology Science, Nankai University, College of Life Science, 2003
Published Work
- Wang Y., Douville C., Cohen J.D., Mattox A., Curtis S., Silliman N., Popoli M., Ptak J., Dobbyn L., Nehme N., Dudley J.C., Summers M., Zhang M., Ho-Pham L.T., Tran B.N.H., Tran T.S., Nguyen T.V., Bettegowda C., Papadopoulos N., Kinzler K.W., Vogelstein B., “Detection of Rare Mutations, Copy Number Alterations, and Methylation in the Same Template DNA Molecules,” Proceedings of the National Academy of Sciences USA, 2023 Apr 11; 120(15):e2220704120, https://www.pnas.org/doi/full/10.1073/pnas.2220704120
- Yuri Laguna Terai, Chun Huang, Baoli Wang, Xiaonan Kang, Jing Han, Jacqueline Douglass, Emily Han-Chung Hsiue, Ming Zhang, Raj Purohit, Taylor deSilva, Qing Wang, “Valid-NEO: A Multi-Omics Platform for Neoantigen Detection and Quantification from Limited Clinical Samples,” Cancers (Basel), 2022 Feb 28;14(5):1243, https://doi.org/10.3390/cancers14051243
- Lihong Li, Maria Facadio Antero, Ming Zhang, Tiffany Chu, Tamer Seckin, Ayse Ayhan, Thomas Pisanic, Tian-Li Wang, Leslie Cope, James Segars, Ie-Ming Shih, “Mutation and Methylation Profiles of Ectopic and Eutopic Endometrial Tissues,” Journal of Pathology, 2021 Aug 16, https://doi.org/10.1002/path.5778
- Qing Wang, Jacqueline Douglass, Michael S. Hwang, Emily Han-Chung Hsiue, Brian J. Mog, Ming Zhang, Nickolas Papadopoulos, Kenneth W. Kinzler, Shibin Zhou, and Bert Vogelstein, “Direct Detection and Quantification of Neo-Antigens,” Cancer Immunology Research, 2019 Nov; 7(11): 1748–1754.5, https://doi.org/10.1158/2326-6066.CIR-19-0107
- Zhang M., Iyer R.R., Azad T.D., Wang Q., Garzon-Muvdi T., Wang J., Liu A., Burger P., Eberhart C., Rodriguez F.J., Sciubba D.M., Wolinsky J.P., Gokaslan Z., Groves M.L., Jallo G.I., Bettegowda C., “Genomic Landscape of Intramedullary Spinal Cord Gliomas,” Scientific Reports, 2019 Dec 10;9(1):18722, https://doi.org/10.1038/s41598-019-54286-9.
- Bettegowda C., Yip S., Jiang B., Wang W.L., Clarke M.J., Lazary A., Gambarotti M., Zhang M., Sciubba D.M., Wolinsky J.P., Goodwin C.R., McCarthy E., Germscheid N.M., Sahgal A., Gokaslan Z.L., Boriani S., Varga P.P., Fisher C.G., Rhines L.D., “Prognostic Significance of hTERT (Human Telomerase Reverse Transcriptase) Promoter Region Mutations C228T and C250T for Overall Survival in Spinal Chordomas,” Neuro-Oncology, 2019 Apr 12, https://doi.org/10.1093/neuonc/noz066.
- Wu R.C.*, Wang P.*, Lin S.F.*, Zhang M.*, Song Q., Chu T., Wang B.G., Kurman R.J., Vang R., Kinzler K., Tomasetti C., Jiao Y., Shih I.M., Wang T.L., “Genomic Landscape and Evolutionary Trajectories of Ovarian Cancer Precursor Lesions,” Journal of Pathology, 2019 May;248(1):41-50, https://doi.org/10.1002/path.5219
- Makohon-Moore A.P.*, Matsukuma K.*, Zhang M.*, Reiter J.G., Gerold J.M., Jiao Y., Sikkema L., Attiyeh M.A., Yachida S., Sandone C., Hruban R.H., Klimstra D.S., Papadopoulos N., Nowak M.A., Kinzler K.W., Vogelstein B., Iacobuzio-Donahue C.A., “Precancerous Neoplastic Cells Can Move Through the Pancreatic Ductal System,” Nature, 2018 Sep;561(7722):201-205, https://doi.org/10.1038/s41586-018-0481-8.
- Gallia G.L.*, Zhang M.*, Ning Y., Haffner M.C., Batista D., Binder Z.A., Bishop J.A., Hann C.L., Hruban R.H., Ishii M., Klein A.P., Reh D.D., Rooper L.M., Salmasi V., Tamargo R.J., Wang Q., Williamson T., Zhao T., Zou Y., Meeker A.K., Agrawal N., Vogelstein B., Kinzler K.W., Papadopoulos N., Bettegowda C., “Genomic Analysis Identifies Frequent Deletions of Dystrophin in Olfactory Neuroblastoma,” Nature Communications, 2018 Dec 21;9(1):5410, https://doi.org/10.1038/s41467-018-07578-z
- Wang Q., Zhang M., Tomita T., Vogelstein J.T., Zhou S., Papadopoulos N., Kinzler K.W., Vogelstein B., “Selected Reaction Monitoring Approach for Validating Peptide Biomarkers,” Proceedings of the National Academy of Sciences USA, 2017 Dec 19;114(51):13519-13524, https://doi.org/10.1073/pnas.1712731114
- Anglesio M.S., Papadopoulos N., Ayhan A., Nazeran T.M., Noë M., Horlings H.M., Lum A., Jones S., Senz J., Seckin T., Ho J., Wu R.C., Lac V., Ogawa H., Tessier-Cloutier B., Alhassan R., Wang A., Wang Y., Cohen J.D., Wong F., Hasanovic A., Orr N., Zhang M., Popoli M., McMahon W., Wood L.D., Mattox A., Allaire C., Segars J., Williams C., Tomasetti C., Boyd N., Kinzler K.W., Gilks C.B., Diaz L., Wang T.L., Vogelstein B., Yong P.J., Huntsman D.G., Shih I.M., “Cancer-Associated Mutations in Endometriosis Without Cancer,” New England Journal of Medicine, 2017 May 11;376(19):1835-1848, https://www.nejm.org/doi/full/10.1056/NEJMoa1614814
- Holdhoff M., Cairncross G.J., Kollmeyer T.M., Zhang M., Zhang P., Mehta M.P., Werner-Wasik M., Souhami L., Bahary J.P., Kwok Y., Hartford A.C., Chakravarti A., Yegnasubramanian S., Vogelstein B., Papadopoulos N., Kinzler K., Jenkins R.B., Bettegowda C., “Genetic Landscape of Extreme Responders With Anaplastic Oligodendroglioma,” Oncotarget, 2017 May 30;8(22):35523-35531, https://doi.org/10.18632/oncotarget.16773
- Alvin P. Makohon-Moore*, Ming Zhang*, Johannes G. Reiter, Ivana Bozic, Benjamin Allen, Deepanjan Kundu, Krishnendu Chatterjee, Fay Wong, Yuchen Jiao, Zachary A. Kohutek, Jungeui Hong, Marc Attiyeh, Breanna Javier, Laura D. Wood, Ralph H. Hruban, Martin A. Nowak, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Christine A. Iacobuzio-Donahue, “Limited Heterogeneity of Known Driver Gene Mutations Among the Metastases of Individual Pancreatic Cancer Patients,” Nature Genetics, 2017 Mar;49(3):358-366. (IF: 31.6). https://doi.org/10.1038/ng.3764
- Chetan Bettegowda*, Stephen Yip*, Sheng-Fu Larry Lo, Charles G. Fisher, Stefano Boriani, LaurenceD. Rhines, Joanna Y. Wang, Aron Lazary, Marco Gambarotti, Wei-Lien Wang, Alessandro Luzzati, Mark B. Dekutoski, Mark H. Bilsky, Dean Chou, Michael G. Fehlings, Edward F. McCarthy, Nasir A. Quraishi, Jeremy J. Reynolds, Daniel M. Sciubba, Richard P. Williams, Jean-Paul Wolinsky, Patricia L.Zadnik, Ming Zhang, Niccole M. Germscheid, Vasiliki Kalampoki, Peter Pal Varga, Ziya L. Gokaslan, “AOSpine Knowledge Forum Tumor. Spinal Column Chordoma: Prognostic Significance of Clinical Variables and T (Brachyury) Gene SNP rs2305089 for Local Recurrence and Overall Survival,” Neuro-Oncology, 2017 Mar 1;19(3):405-413. (IF: 7.4). https://doi.org/10.1093/neuonc/now156
- Mark W. Ball, Michael H. Johnson, Michael A. Gorin, Maria A. Mendoza Rodriguez, Ming Zhang, Nickolas Papadopoulos, Michael C. Haffner, Hans J. Hammers, Luigi Marchionni, George J. Netto, Charles G. Drake, Mohamad E. Allaf, “Clinical, Pathologic, and Genomic Profiles of Exceptional Responders to Anti-PD1 Therapy in Renal Cell Carcinoma,” Cancer Immunology Research, Accepted in Feb 2016. (IF: 3.9). https://doi.org/10.1200/jco.2016.34.2_suppl.625
- Robles A.I.*, Traverso G.*, Zhang M.*, Roberts N.J., Khan M.A., Joseph C., Lauwers G.Y., Selaru F.M., Popoli M., Pittman M.E., Ke X., Hruban R.H., Meltzer S.J., Kinzler K.W., Vogelstein B., Harris C.C., Papadopoulos N., “Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers,” Gastroenterology, 2016 Apr;150(4):931-43. (IF: 16.7). https://doi.org/10.1053/j.gastro.2015.12.036
- Mark Ball, Michael Johnson, Michael Gorin, Maria Rodriguez, Ming Zhang, Nick Papadopoulos, Michael Haffner, Hans Hammers, Luigi Marchionni, George Netto, Charles Drake, Mohamad Allaf, “MP03-01 Clinical, Pathologic, and Genomic Profiles of Exceptional Responders to Anti-PD1 Therapy in Renal Cell Carcinoma,” Journal of Urology, 195 (4), e19, https://doi.org/10.1016/S0022-5347(16)03382-6
- Wang Y.*, Springer S.*, Zhang M.*, McMahon K.W., Kinde I., Dobbyn L., Ptak J., Brem H., Chaichana K., Gallia G.L., Gokaslan Z.L., Groves M.L., Jallo G.I., Lim M., Olivi A., Quinones-Hinojosa A., Rigamonti D., Riggins G.J., Sciubba D.M., Weingart J.D., Wolinsky J.P., Ye X., Oba-Shinjo S.M., Marie S.K., Holdhoff M., Agrawal N., Diaz L.A. Jr., Papadopoulos N., Kinzler K.W., Vogelstein B., Bettegowda C., “Detection of Tumor-Derived DNA in Cerebrospinal Fluid of Patients With Primary Tumors of the Brain and Spinal Cord,” Proceedings of the National Academy of Sciences USA, 2015 Aug 4;112(31):9704-9. (IF: 9.7). https://doi.org/10.1073/pnas.1511694112
- Dal Molin M.*, Zhang M.*, de Wilde R.F.*, Ottenhof N.A., Rezaee N., Wolfgang C.L., Blackford A., Vogelstein B., Kinzler K.W., Papadopoulos N., Hruban R.H., Maitra A., Wood L.D., “Very Long-Term Survival Following Resection for Pancreatic Cancer Is Not Explained by Commonly Mutated Genes: Results of Whole-Exome Sequencing Analysis,” Clinical Cancer Research, 2015 Apr 15;21(8):1944-50. (IF: 8.7). https://doi.org/10.1158/1078-0432.CCR-14-2600
- Llosa N.J., Cruise M., Tam A., Wicks E.C., Hechenbleikner E.M., Taube J.M., Blosser R.L., Fan H., Wang H., Luber B.S., Zhang M., Papadopoulos N., Kinzler K.W., Vogelstein B., Sears C.L., Anders R.A., Pardoll D.M., Housseau F., “The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints,” Cancer Discovery, 2015 Jan;5(1):43-51. (IF: 19.5). https://doi.org/10.1158/2159-8290.CD-14-0863
- Zhang M., Wang Y., Jones S., Sausen M., McMahon K., Sharma R., Wang Q., Belzberg A.J., Chaichana K., Gallia G.L., Gokaslan Z.L., Riggins G.J., Wolinksy J.P., Wood L.D., Montgomery E.A., Hruban R.H., Kinzler K.W., Papadopoulos N., Vogelstein B., Bettegowda C., “Somatic Mutations of SUZ12 in Malignant Peripheral Nerve Sheath Tumors,” Nature Genetics, 2014 Nov;46(11):1170-2. (IF: 31.6). https://doi.org/10.1038/ng.3116
- Killela P.J., Reitman Z.J., Jiao Y., Bettegowda C., Agrawal N., Diaz L.A. Jr., Friedman A.H., Friedman H., Gallia G.L., Giovanella B.C.., Grollman AP., He T.C., He Y., Hruban R.H., Jallo G.I., Mandahl N., Meeker A.K., Mertens F., Netto G.J., Rasheed B.A., Riggins G.J., Rosenquist T.A., Schiffman M., Shih Ie-M., Theodorescu D., Torbenson M.S., Velculescu V.E., Wang T.L., Wentzensen N., Wood L.D., Zhang M., McLendon R.E., Bigner D.D., Kinzler K.W., Vogelstein B., Papadopoulos N., Yan H., “TERT Promoter Mutations Occur Frequently in Gliomas and a Subset of Tumors Derived From Cells With Low Rates of Self-Renewal,” Proceedings of the National Academy of Sciences USA, 2013 Apr 9;110(15):6021-6. (IF: 9.7). https://doi.org/10.1073/pnas.1303607110
- Mi D.*, Zhang M*, Yan J.D., Zhang J., Wang X., Wang Q., Yang S., Zhu T.H., “PTHrP Inhibits BMP-6 Expression Through the PKA Signaling Pathway in Breast Cancer Cells,” Journal of Cancer Research and Clinical Oncology, 2011 137(2):295-303. https://doi.org/10.1007/s00432-010-0883-y
- Shu B., Zhang M., Xie R., Wang M., Jin H., Hou W., Tang D., Harris S.E., Mishina Y., O’Keefe R.J., Hilton M.J., Wang Y., Chen D, “BMP2, But Not BMP4, Is Crucial for Chondrocyte Proliferation and Maturation During Endochondral Bone Development,” Journal of Cell Science, 2011 124(Pt 20):3428-40. https://doi.org/10.1242/jcs.083659
- Zhang M., Wang M., Tan X., Li T.F., Zhang Y.E., Chen D., “Smad3 Prevents Beta-Catenin Degradation and Facilitates Beta-Catenin Nuclear Translocation in Chondrocytes,” Journal of Biological Chemistry, 2010 Mar 19;285(12):8703-10. https://doi.org/10.1074/jbc.M109.093526
- Zhang M., Xie R., Hou W., Wang B., Shen R., Wang X., Wang Q., Zhu T., Jonason J.H., Chen D., “PTHrP Prevents Chondrocyte Premature Hypertrophy by Inducing Cyclin D1-Dependent Runx2 and Runx3 Phosphorylation, Ubiquitination, and Proteasome Degradation,” Journal of Cell Science, 2009 122: 1382-9. https://doi.org/10.1242/jcs.040709
- Zhang M., Yan Y., Lim Y.B., Tang D., Xie R., Chen A., Tai P., Harris S.E., Xing L., Qin Y.X., Chen D., “BMP-2 Modulates β-Catenin Signaling Through Stimulation of Lrp5 Expression and Inhibition of β-TrCP Expression In Osteoblasts,” Journal of Cellular Biochemistry, 2009 1;108(4):896-905. https://doi.org/10.1002/jcb.22319
- Zhang M., Wang Q., Yuan W., Yang S., Wang X., Yan J.D., Du J., Yin J., Gao S.Y., Sun B.C., Zhu T.H., “Epigenetic Regulation of Bone Morphogenetic Protein-6 Gene Expression in Breast Cancer Cells,” Journal of Steroid Biochemistry and Molecular Biology, 2007 105(1-5):91-7. https://doi.org/10.1016/j.jsbmb.2007.01.002
- Yang S., Du J., Wang Z., Yuan W., Qiao Y., Zhang M., Zhang J., Gao S., Yin J., Sun B., Zhu T., “BMP-6 Promotes E-Cadherin Expression Through Repressing DeltaEF1 in Breast Cancer Cells,” BMC Cancer, 2007 7:211. https://doi.org/10.1186/1471-2407-7-211
- Yang S., Zhao L., Yang J., Chai D., Zhang M., Zhang J., Ji X., Zhu T., “DeltaEF1 Represses BMP-2-Induced Differentiation of C2C12 Myoblasts Into the Osteoblast Lineage,” Journal of Biomedical Science, 2007 14(5):663-79. https://doi.org/10.1007/s11373-007-9155-5
- Wang Q., Wei X., Zhu T., Zhang M., Shen R., Xing L., O’Keefe R.J., Chen D., “BMP-2 Activates Smad6 Gene Transcription Through Bone-Specific Transcription Factor Runx2,” Journal of Biological Chemistry, 2007 282(14):10742-8. https://doi.org/10.1074/jbc.M610997200
- Wang Q., Zhang M., Wang X., Yuan W., Chen D., Royer-Pokora B., Zhu T., “A Novel Transcript of the LMO2 Gene, LMO2-c, Is Regulated by GATA-1 and PU.1 and Encodes an Antagonist of LMO2,” Leukemia, 2007 21(5):1015-25. https://doi.org/10.1038/sj.leu.2404644
- Zhang M., Yan J., Zhang L., Wang Q., Lv S., Zhang J., and Zhu T., “Activation of Bone Morphogenetic Protein-6 Gene Transcription in MCF-7 Cells by Estrogen,” Chinese Medical Journal (Peking), 2005 118(19):1629-36. https://pubmed.ncbi.nlm.nih.gov/16232348/
*Co-first author